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This straightforward synthetic route is a variation of the synthesis outlined in The synthetic route shown in Scheme 7 also allows ready access to other substituted amine analogs that can be explored, and that may be more resistant to metabolism, as they do not have a benzylic position to react with P450s

Additional Reviews Already Scheduled The announcement also outlines next steps, making clear that this is not the final word on these therapies

Sep 2006;17(8):881-889