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This enhances aquaporin-4 expression, ultimately reducing astrocyte viability and causing cellular edema (147, 148)

To examine this, conditional myeloid SOCS3 knockout mice (SOCS3MyeKO) with EO771 mammary tumors were developed, demonstrating a significant presence of tumor-infiltrating eMDSCs and enhanced immunosuppression both in vitro and in vivo

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Injection timing within either schedule matters significantly

however, its potential cardiotoxicity can lead to cardiomyopathy and calcium metabolism disturbances