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In 2025, the oncology field saw a notable increase in smallmolecule approvals and a greater reliance on response rate as the primary efficacy endpoint for accelerated and regular approvals

An example for this latter mechanism is Trx oxidation by the Prx dimer (as in Fig

Furthermore, a study revealed that the anterior vaginal wall of SUI rats presented considerably higher expression of TR-2 and Smad7 than that of blank-treated and control rats

Niu X, Chen L, Li Y, Hu Z, He F

Abstract The increasing incidence of oral malignancies, coupled with the limitations of conventional treatments such as toxicity and drug resistance, has driven the exploration of novel therapeutic approaches

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