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In these cases, the mathematical modelling is altered to apply to continua, but the principles remain the same

63 Therapeutic Implications of the Wnt/-Catenin Pathway in DKD As previously stated, DKD and the disruption of Wnt signaling pathways are closely related

The challenge is that many of these chemicals also display other mechanisms of action, for example antagonizing the AR

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Fusion primers with dual-indexed PCR adapters were used to generate the construct library, and short fragments were removed with AMPure beads