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VIP and immune cell modulation VIP interacts with multiple immune cells through specific receptors (VPAC-1, VPAC-2, CRTH2, and PAC1) expressed on eosinophils, mast cells, neutrophils, lymphocytes, dendritic cells, NK cells, and macrophages

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doi: 10.3390/healthcare8030192 [DOI] [PMC free article] [PubMed] [Google Scholar] 394

The second mechanism involves the nuclear transcription factor NRF2 (nuclear factor erythroid 2-related factor 2), which governs the cell's antioxidant defense network

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