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In addition, glutathione acts as a scavenger of hydroxyl radicals and nascent oxygen

Decreased erythropoietin production : Erythropoietin is produced in renal interstitial cells

72 Tocilizumab, a humanized anti-IL-6 receptor antibody, has been developed and approved for the treatment of rheumatoid arthritis and juvenile idiopathic arthritis

The disturbance of endoplasmic reticulum Ca2+ triggered by oxidative stress may also induce UPR and apoptosis ( + T cells to produce adaptive immune response, and T cells release interferon- (INF-), It binds to receptors on keratinocytes, further releases and presents inflammatory cytokines such as CXC-L16 and IL-15, and further recruits T cells to the skin through a positive feedback loop ( + and T cells induced by cytokines and chemokines ensure the final destruction of epidermal melanocytes (Figure 1)