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To determine whether MNNG induces the nuclear translocation of p53 protein, NA cells were treated with MNNG for 24 h and the localization of p53 protein was visualized by immunofluorescence

But it is the ability of these enzyme systems to chemically alter drugs to facilitate the effective excretion and elimination of these substances from the body to provide important protection against drug toxicity

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Methylmercury demonstrates its toxic effects primarily by binding to sulfhydryl groups and inhibiting cholinesterase activity, whereas various pesticides impair neural function by prolonging sodium channel opening, inhibiting GABA receptors, or blocking acetylcholine esterase activity [32]

(B) in focal or non-specific hepatitis, scattered foci of cell necrosis may accompany lymphocytic infiltration

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