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Panax Ginseng: A medicinal root with a long use history as an adaptogen, the mechanistic evidence for this ingredient suggests an increase in dopaminergic and cholinergic neurotransmission

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EGFR activation leads to induction of MAPK signaling (via p38, ERK1/2) and the activation of c-Fos (Naglik et al., 2019), ultimately triggering the production of inflammatory mediators such as G-CSF and GM-CSF (Nikou et al., 2022), and the activation of the NLRP3 inflammasome leads to the release of IL-1 (Rogiers et al., 2019)

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doi: 10.1016/j.brainres.2022.148022 [DOI] [PubMed] [Google Scholar] 146

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