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A structural explanation for these findings was provided from our previous cryo-EM structures of CT(Pro32) and rAmy(Tyr37)-bound AMYRs structures where the bulky phenolic side chain of Y37 rAmy forms perpendicular stacking interactions with W79 ECD 15 , and additional interactions with the respective RAMP protomer that are likely important for selectivity of rAmy for AMYRs over CTR

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Athletes regularly deal with the natural wear and tear they place on their muscles and joints

Telomeres, the protective caps at the end of chromosomes, naturally shorten with age, leading to cellular aging and reduced function

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MOTS-c is typically administered in the morning to align with metabolic activity cycles