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PIKFYVE inhibition mitigates disease in models of diverse forms of ALS

Mar 1 2020;155(3):243-249

Leber, D

First, to our knowledge, current study is the first comprehensive systematic review and meta-analysis addressing this issue, so far

R- and R2-viniferins: both are highly cytotoxic in vitro, with R2-viniferin showing stronger potency in HepG2 cells with an IC50 of 9.7 M, 3 more potent than resveratrol (Aja et al