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Endocrine irAEs can be insidious in onset and usually present with hypophysitis with diminished downstream thyroid and adrenal steroid production, or occasionally with severe headache as the pituitary becomes acutely inflamed [28]

It is also important for the normal function and development of the brain and the nerve cells

The cDNAs encoding human GHSR was cloned into the pcDNA3.1(+) vector (Invitrogen) with a FLAG peptide fused to the N terminus

Studies have found that NOK is positively expressed in tumor cells of NSCLC patients, and it is significantly correlated with the degree of lung tumor differentiation and lymphatic metastasis [117]

However, the researchers only observed this increase in younger adults

doi: 10.3389/fnhum.2018.00001 22