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As summarized in Table 4, preclinical and clinical studies support cardioprotective effects of metformin across diverse cardiac conditions, but large, rigorously designed trials are needed to define its role beyond metabolic indications

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Keyword combinations included viral pneumonia, Traditional Chinese Medicine, natural products, inflammation, and oxidative stress, in addition to mechanism-related terms such as NF-B, Nrf2, PI3K/Akt, MAPK, and NLRP3 inflammasome. Natural compounds acting on these pathways have been shown to suppress cytokine storms, reduce reactive oxygen species accumulation, preserve alveolar epithelial integrity, and alleviate pulmonary inflammation

Germline-encoded naturally occurring autoantibodies (NOAbs) then bivalently bind to these structures on the cell membrane, thereby becoming necessary to selectively clear aged RBCs [219]

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