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Discovered in the 1980s, it is known to support melatonin production, improving sleep cycles and immune function, which decline with age

Neurovascular unit dysfunction with blood-brain barrier hyperpermeability contributes to major depressive disorder: a review of clinical and experimental evidence

38,39 Glutamine traverses the plasma membrane via amino acid transporter type 2 (ASCT2) and sodium-coupled neutral amino acid transporter 5 (SN2), where cytosolic glutaminase converts it to glutamate and then to -ketoglutarate (-KG), which enters the TCA cycle

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Prior to analyses, all samples were stored in liquid nitrogen to keep the integrity of cellular proteins

doi: 10.1016/S0749-3797(98)00017-8 10 WadeJRCronholmPFFeinJAForkeCMDavisMBHarkins-SchwarzMet al