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mTOR inhibition not only impaired mitochondrial ATP turnover, but abolished the positive effect of Exendin-4 on this parameter (Fig

Deyno S, Eneyew K, Seyfe S, et al

Amplex-type assays report pooled H 2 O 2 and therefore integrate multiple mitochondrial and extra-mitochondrial sites, so accurate source attribution requires site-specific probes (including genetically encoded reporters targeted to matrix, IMS, or outer membrane) and carefully controlled substrate and inhibitor protocols that isolate individual electron-transfer nodes (Waldeck-Weiermair et al

Common culprit drugs in DRESS include AEDs (carbamazepine, lamotrigine, phenobarbital, phenytoin), antibiotics (amoxicillin, ampicillin, azithromycin, levofloxacin, minocycline), anti-tuberculosis agents (ethambutol, isoniazid, rifampicin, pyrazinamide), analgesics (diclofenac, ibuprofen, aspirin, celecoxib), sulfonamides (dapsone, sulfamethoxazole-trimethoprim, sulfasalazine), anti-viral (abacavir, nevirapine), anti-hypertensive (amlodipine, captopril), allopurinol, and amitriptyline