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Adrenal adenomas are the most prevalent adrenal tumor type and are typically nonfunctional, meaning they do not produce excessive hormones ( 3.4 Adrenal steroidogenesis The pathophysiology of lethal adrenal disorders is heavily influenced by oxidative stress, and mutations in antioxidant defense genes can have a considerable impact on adrenal steroidogenesis

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Multiparameter metabolic analysis reveals a close link between attenuated mitochondrial bioenergetic function and enhanced glycolysis dependency in human tumor cells

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Research utilizing obese mouse models has demonstrated that dietary supplementation with antioxidants results in a reduction of oxidative stress markers [104, 105]