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Resveratrol, a promising pigment-lightening flavonoid found in red wine, was recently found to suppress TYR expression not via the inhibition of MITF expression, but by directly inhibiting TYR activity by a post-translational modification that reduces the levels of fully mature TYR protein (119)

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Mondal et al, 2019

Mechanistically, mTORC1 promotes the proteasome-mediated destabilization of CREB2 to suppress SIRT4 (a mitochondria-localized member of the sirtuin family), which inhibits GDH, thereby enhancing GDH enzymatic activity

Differential targeting of GSH1 and GSH2 is achieved by multiple transcription initiation: implications for the compartmentation of glutathione biosynthesis in the Brassicaceae

has served as an adviser to Boehringer Ingelheim, Ferring, Genentech, GlaxoSmithKline, Gilead, Hospira, Janssen, Pfizer, and VHSquared