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IC50 was calculated according to cell viability using the nonlinear regression analyses in GraphPad Prism 10.0 software

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Therefore, while buprenorphine plasma levels will increase with repeated dosing (reaching an average concentration of 6.3 ng/mL and peak concentration of 11.8 ng/mL with 300 mg monthly at steady state [12]), a moderate and transient increase in peak plasma concentration up to 52% (17.9 ng/mL) is not expected to impact patients safety

However, their effectiveness can wane over time

However, there are some general guidelines that can be helpful to keep in mind

This helps reduce Wegovy injection site irritation or soreness