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Nose-to-brain delivery has been used in several clinical trials for AD over the last decades

Glob J Nanomed 1(5):555573

Traumatic brain injury, neuroinflammation, and post-traumatic headaches

doi: 10.1016/j.mito.2024.101975 121 MorrisGGevezovaMSarafianVMaesM

Patients were subjected to different doses of it once a day, and the group given the 1mg dose lost the most weight, triple that of the control group, and showed small but consistent improvement in cholesterol levels too