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Effects of Astragalus polysaccharide on depressive behaviors and hippocampal Nrf2-ARE signaling pathway in rats

Oncogene 43 (5), 295303

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Under normoxic conditions, the alpha subunits of HIF are usually targeted for ubiquitination by the hydroxylation of prolyl particles and, later, are connected with von Hippel Lindau (VHL) proteins, leading to end-stage HIF alpha subunit degradation