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2.2 Mitochondrial ROS in tumor immunity Mitochondria are the main intracellular ROS-generating organelles, producing ROS through the electron transport chain (ETC) and OXPHOS during aerobic respiration ( 2.2.1 ROS and formation of a tumor immunosuppressive microenvironment As highlighted in the previous section, ROS plays a central regulatory role in the TME and drives cancer development and progression ( 2.2.2 Effects of mtROS on immune cell activation in the TME To avoid the deleterious effects of high ROS levels on immune cells, there exists a set of strict regulatory mechanisms in the organism to maintain a delicate balance between immune cell activity and ROS levels ( Figure 3 )

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