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An Affront to Health Freedom: The FDA Recategorizes 17 Therapeutic Peptides

PLoS ONE 2018, human dorsal-root-ganglion neurons: GLP-1R agonists do not excite nociceptors directly and have no effect on capsaicin/TRPV1 responses but enhance ATP/P2X signaling, so TRPV1 is excluded as the channel

Patients who have a compromised gastrointestinal system (with a low production of intrinsic factor) are not able to absorb enough vitamin B12 from food or a pill form

Prevalence of folic acid and vitamin B12 deficiencies in patients with thyroid disorders

Results: GHK-Cu alleviated weight loss, improved the disease activity index (DAI), reduced colonic edema and shortening, attenuated inflammatory damage, increased goblet cell numbers, suppressed inflammatory cytokines such as TNF-, IL-6, and IL-1, and promoted mucosal repair

Key facts from Pickarts original studies: GHK-Cu exists in the plasma of all healthy adults The concentration decreases with age , from ~200 ng/ml in 20-year-olds to ~80 ng/ml in 60-year-olds This decline correlates with the age-related loss of regenerative capacity of tissue Cu is essential for the biological activity, GHK without copper has a dramatically weaker effect These original observations launched a 50-year research program that today covers thousands of publications in dermatology, wound healing, ageing research and regenerative medicine