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however, Asian-Indian and Filipino individuals have been found to have higher risks than other racial groups

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This schematic highlights how curcumin disrupts key inflammatory cascades such as the IKK/NF-B pathway, shifts immune cell phenotypes toward anti-inflammatory states, suppresses the expression of pro-fibrotic factors such as TGF- and CTGF, and promotes the apoptosis of inflammatory cells

Li TY, Zhang XY, Cheng LL, et al

237 The therapeutic effects of the amino salicylic acid class drug sulfalazine, 238 the antibiotics azithromycin and buspirone, 239 the opioid agonist human opiorphin, 240 the PDE5 inhibitor sildenafil 241 and many other commonly used clinical drugs in UC are attributed to the inhibition of the NFB pathway, which inhibits the expression of inflammatory cytokines and the infiltration of inflammatory cells, alleviating intestinal epithelial damage

Plant Cell 6 , 17131729 (1994)