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introduced polar substituents, including hydroxyl, sulfanilamide, carboxyamide, and carboxylic groups, to reduce the alkalinity and lipophilicity of second-generation 4-H HAP analogs

Experiments in mice show that female mice are much less sensitive to acetaminophen overdose [17,18]

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Although subgroup analyses found significant heterogeneity regardless of assay type, literature suggests that different assays have specific characteristics and potential pitfalls [82]