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In vitro , -elemene (a ferroptosis inducer) in combination with cetuximab was shown to induce iron-dependent ROS accumulation, GSH depletion, lipid peroxidation, upregulation of HO-1 and transferrin, and downregulation of GPX4, SLC7A11 and other negative regulatory proteins in KRAS mutant CRC cells ( In vivo , co-treatment with -elemene and cetuximab inhibited KRAS mutant tumor growth and lymph nodes metastases ( Pancreatic cancers The main reason for the poor prognosis of PDAC is the late diagnosis of the disease and resistance to drugs that induce apoptosis (Yang G

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EC 4.1.2.13) catalyzes the reversible conversion of fructose 1,6-bisphosphate to glyceraldehyde 3-phosphate and dihydroxyacetone phosphate

During metabolism most drugs lose the pharmacological activity and are excreted from the body

At the same time, rosmarinic acid promotes the upregulation of TH and brain-derived neurotrophic factor (BDNF) genes to alleviate the cytotoxicity of H 2 O 2 -induced N2A cells (Ghaffari et al., 2014)

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