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ICD-10-CM anatomic code blocks for malignant neoplasms are organized by primary site (per CDC NCHS ICD-10-CM tabular list): C00C14: Lip, oral cavity, pharynx C15C26: Digestive organs (C18 colon, C19 rectosigmoid junction, C20 rectum, C22.0 hepatocellular carcinoma, C22.1 intrahepatic cholangiocarcinoma, C25 pancreas) C30C39: Respiratory system (C34.xx lung requiring laterality and lobe specificity) C40C41: Bone and articular cartilage C43C44: Skin (C43 melanoma, C44 other malignant skin neoplasms) C45: Mesothelioma C50.xxx: Breast requires quadrant (09) AND laterality (1 right, 2 left, 9 unspecified) C51C58: Female genital organs (C56.x ovary, C53 cervix, C54 uterus) C60C63: Male genital organs (C61 prostate) C64C68: Urinary tract (C64 kidney, C67 bladder) C69C72: Eye, brain, and CNS (C71.x brain by lobe) C73C75: Thyroid and endocrine glands (C73 thyroid) C76C80: Ill-defined, secondary, and unspecified sites (C80.1 malignant neoplasm without specified site) C81C96: Lymphoid, hematopoietic, and related tissue C7A: Malignant carcinoid tumors