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Emerging non-canonical functions and regulation by p53: p53 and stemness

It is rapidly converted to acetate by aldehyde dehydrogenase (ALDH) within the mitochondria and cytosol ( (2) The Microsomal Ethanol Oxidizing System (MEOS): This pathway involves the metabolism of ethanol to acetaldehyde in the mitochondria, converting NADPH and O 2 into oxidized nicotinamide adenine dinucleotide phosphate (NADP+) and H 2 O, while simultaneously producing ROS (Lu and Cederbaum, 2008)

[7] [15] [16] A small randomized trial of 70 euthyroid patients with untreated, severe TED assigned to either weekly IV methylprednisolone (0.5 g then 0.25 g weekly for six weeks each) or highdose oral prednisone (100 mg/day tapered by 10 mg/week), the IV group demonstrated higher response rates at 3 months, greater improvements in visual acuity, chemosis, and quality of life, and fewer adverse events

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10.1016/j.imr.2019.11.002 45

Biochemically, the deposition of intracellular iron, abundance of reactive oxygen species (ROS) and aggregation of lipid peroxides are manifested during the occurrence of ferroptosis[12]