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O.GopalkrishnanA.et al (2006)

It is activated in response to a wide variety of signals, such as those conveyed by Rap1A and Ras, through a mechanism that involves its C-terminal Ras association (RA) domains (RA1 and RA2)

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The author later injected serum from patients with GD into himself and his colleagues to show the presence of stimulating activity

After silencing the expression of GDF15, the levels of SOD and GSH decreased, while the level of MDA increased, and the anti-ferroptosis effect of VB was weakened