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Tumour necrosis factor- induces the release of ROIs (Goossens et al, 1995) that are also considered to be potent NF- B activators in many cell types, including tumour cells (Giri et al, 1998

It also promotes the metabolism of arachidonic acid, enhancing the activity of various enzymes and free radicals

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Concurrently, leucine is recognized as a potent stimulator of the mTORC1 pathway, thereby fostering translational initiation, MPS, and the inhibition of proteolysis (13)

10.1016/j.mito.2009.11.001 Mitochondrion 287 LongeckerM

Beyond direct cytotoxicity, we critically examine the synergistic interplay between ferroptosis and the tumor immune microenvironment (TME)