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Ohara et al

Regulation of mouse sterol regulatory element-binding protein-1c gene (SREBP-1c) by oxysterol receptors, LXR and LXR

no consistent signal for organ toxicity or long-term harm across decades of use Special Populations: Clinical experience exists in elderly patients with dementia and stroke patients, populations where safety data is particularly valuable IV Administration Considerations: Requires clinical administration setting for intravenous dosing, which limits convenience but ensures medical oversight Dihexa: Unknown Human Safety Profile Dihexa has never been administered to humans in any controlled setting, creating a complete absence of human safety data: No Human Pharmacokinetics: Absorption, distribution, metabolism, and excretion parameters are unknown in humans Theoretical c-Met Oncogenesis Concern: The c-Met/HGF pathway is implicated in cancer progression aberrant c-Met signaling promotes tumor growth, metastasis, and angiogenesis in multiple cancer types

Strength: 1,000mcg/mL (10,000mcg/10mL) Bacteriostatic water and mixing syringe will be provided for reconstitution

The most common effects include gastrointestinal disorders (nausea, stomach ache, indigestion, diarrhoea), especially in seniors, as well as allergic skin reactions such as rashes, redness, inflammation and itching, and in some cases even urticaria