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While current mRNA vaccine regimens typically involve booster doses every 34 weeks, therapeutic applications such as protein replacement therapy or in vivo cellular engineering may require more frequent dosingon the order of weekly or even more frequent intervals

These findings were recapitulated ex vivo, as young T cells exposed to aged SE (1:16 in culture media, a concentration that did not reduce viability (Extended Data Fig

The liver accumulates most of the Cd that is easily collected

Inadequate endosomal escape can result in reduced efficacy and increased off-target toxicity

Li X, Li J, Wei J, Du W, Su C, Shen X, et al

This compound also markedly increased striatal dopamine levels and boosted SOD activity