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151 CCAAT/enhancer binding protein gamma (CEBPG) is crucial in various biological processes, such as cell proliferation, cell differentiation, and energy metabolism

However, Mateo et al

doi: 10.1073/pnas.2012748118 142 CassagoAFerreiraAPSFerreiraIMFornezariCGomesERMGreeneKSet al

Such vulnerability could originate from the highest levels of immobilized, protein-bound iron, which can be a potent cytotoxin by catalyzing the conversion of hydrogen peroxide to hydroxyl radicals via the Fenton reaction (Connor and Menzies, 1998)

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Instead, these companies prefer to use naturally occurring base structures, e.g., 5mC and 6 mA, to modify certain base(s), probably because of concerns about the safety of the metabolized unnatural residues that potentially might be incorporated into the genome