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CYP-Mediated Pharmacokinetic Interaction: The Unknown Variable Venlafaxine is primarily metabolized by CYP2D6 to its active metabolite O-desmethylvenlafaxine (desvenlafaxine), with CYP3A4 contributing a minor pathway [3]

The IN delivery of poly (lactic-co-glycolic acid) nanoparticles has been shown to improve the efficiency of olanzapine (PLGA) nanoparticle transport to the brain

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Cellular uptake experiments: 200 nmoles aliquots of targeted and non-targeted liposomes were added to an invitro model of blood brain barrier (co-cultures of rat astrocytes and bovine capillary endothelial cells) as well as to single cultures of BCECs