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Katamesh 2 , Mohammad Tanashat 4 , Husam Abusuilik 5 , Obieda Altobaishat 6 , Mohamed Abdelnabi 7 , Hazem Abosheaishaa 8 , Mohamed Ahmed 9 , Basel Abdelazeem 10 and Hassan Ghoz 9 , (1)University of Missouri-Kansas City, (2)Tanta University, (3)Al-Azhar University, (4)Yarmok University, (5)Hashemite University, (6)Jordan University of Science and Technology, (7)University of Michigan, Ann Arbor, Michigan, (8)Icahn School of Medicine at Mount Sinai, (9)University of Missouri- Kansas City, (10)Mclaren Health Care-Flint Background: Non-alcoholic fatty liver disease (NAFLD) is a prevalent metabolic disorder characterized by excessive accumulation of fat in the liver

In normal red blood cells, pentose phosphate pathway and glycolysis are enhanced and G6PD is sufficient to produce NADPH efficiently for GSSG reduction and maintenance of GSH pool (311)

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Taken together, the stabilization of HIF-1 promotes pathogen clearance in mycobacterial infection by the remodeling of metabolic pathways in macrophages, and the effect of HIF-1 can be beneficial or detrimental to the host depending on the infection stages or immune cell activation states ( Table 3 )