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These compounds can covalently react with the thiol group (-SH) of the catalytic cysteine residue of AhpC, thereby inhibiting AhpC activity

The weight loss achieved by CagriSema (-20.4% at 68 weeks) is comparable to that reported with the dual glucose-dependent insulinotropic polypeptide (GIP)/GLP-1 receptor agonist tirzepatide (-20.9% with the 15-mg dose at 72 weeks in SURMOUNT-1) [14]

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Thus any enzyme containing these amino acid can undergo inactivation due to presence of ROS, rendering the enzyme inactive, which in turn blocks the vital biological processes

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