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Description

Evaluation of phosphorus and non-phosphorus neutral oligonucleotide backbones for enhancing therapeutic index of gapmer antisense oligonucleotides

doi: 10.1038/s41419-024-06472-5 84 LvYLiuZDengLXiaSMuQXiaoBet al

W849) for 10 minutes at 37C with 5 g/mL WGA, followed by two PBS washes

Moreover, the increase in GSH levels induced by Nrf2 activation prevents the p75 NTR -mediated apoptosis of neurons in vitro (Vargas et al., 2006)

It may be repeated once the drug reaches steady state

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