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For this comparative study, P-NP (PLGA-GA) emulsiondiffusion evaporation (157 nm size and 52% encapsulation of UA), L-NP (TPGS and tristearin) solvent evaporation (132 nm size and 70% encapsulation of UA), and H-NP (PLGA-GA with tristearin) emulsiondiffusion epoxide (186 nm size and 29% encapsulation of UA) techniques were implemented