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Eric Topol of Scripps Research Translational Institute was more direct: "These peptides have no data to support their safety and efficacy." The clinical proponents argue that the FDA's safety concerns immunogenicity risk, impurity risk, organ toxicity are theoretically valid but speculative in practice

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Dihexa has also been used, independent of the cognition research programme, as one of several small molecules supporting hepatocyte-like differentiation of human pluripotent stem cells in vitro (typically at 100 nM over roughly 10 days of maturation), reflecting its reported HGF-pathway agonism in a non-neuronal cell system