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This principle explains why certain reactions are more favorable than others, even when the energy gaps might be similar

October 14-16 th , 2022 Matthew-Belmar V, N Noel, E Chitan, B Sharma, T Khan, N Cudjoe, B Osei Boakye, P Fields, T Noel, A Alhassan and C Macpherson (2022)

Weber K, Bratzke HJ, Neubert U, Wilske B, Duray PH

NIH Consensus conference

In the initial phase, synthesized free PUFAs, including substances such as arachidonic acid, are transformed into acyl-coenzyme A thioesters (PUFA-CoAs) by the enzyme acyl-CoA synthetase long-chain family member 4 (ACSL4), a reaction necessary for PUFA utilization in membrane lipid synthesis (Figure 2) [34,35]

The prevention strategy for both conditions is identical: adequate hydration