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One point of controversy that has been discussed since the seminal Framingham paper is that in the Framingham cohort up to 35% of CHD incidence occurred in subjects with a total cholesterol level of less than 5.2mmol/L ( 3mmol/L (116mg/dL), which is a sufficient exposure over the course of a 20-40 year period to contribute to atherosclerosis (discussed in LDL section below)

280,281,282 Inositol 1,4,5-trisphosphate (IP3) interacts with IP3R in the ER membrane to release Ca 2+ from the ER lumen

Resveratrol attenuates Trimethylamine-N-Oxide (TMAO)-induced atherosclerosis by regulating TMAO synthesis and bile acid metabolism via remodeling of the gut microbiota

in addition, when melatonin and pregabalin are combined, they have protective and analgesic effects, respectively, and synergistically inhibit vincristine-induced neuropathic pain [50]

SGLT2i, by promoting urinary glucose excretion, ameliorate systemic IR and have been shown to reduce ectopic lipid deposition in muscle and the arterial wall, thereby addressing a key driver of the pathology in both tissues (141)

doi: 10.1016/j.atherosclerosis.2008.08.039 54 HoseiniZ.SepahvandF.RashidiB.SahebkarA.MasoudifarA.MirzaeiH