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When glucose was scarce, the levels of ROS were elevated (Fig

Th17 cells were differentiated from CD4 + T cells in vitro, as previously described 29 , and then treated with or without IGF-1 for an additional 48 h

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10.1038/s41418-017-0012-4 [DOI] [PMC free article] [PubMed] [Google Scholar] Garzotto D., Giacobini P., Crepaldi T., Fasolo A., De Marchis S

This rapid ROS generation is thought to be due not only to the lack of the antioxidant capacity of GSTP but also to mitochondrial damage induced by the loss of GSTP localized in mitochondria