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Homocysteine causes vascular endothelial dysfunction by disrupting endoplasmic reticulum redox homeostasis

There are only certain places in the body where B12 can be absorbed and these are via the oral mucosa in the mouth and in the small intestine

In line with this work, HGF decreases oxidative stress in an Alzheimers disease (AD) transgenic mouse model (Takeuchi et al., 2008)

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If stomach acid levels are low, as can happen with age or certain medications, B12 absorption may be compromised