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Often times, the impurities are highly similar to the desired product, making chromatographic separation difficult and likely time consuming

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The Trojan Horse hypothesis posits that the nanoparticle form facilitates uptake, subsequently dissolving within the acidic confines of organelles like lysosomes to deliver a highly concentrated dose of toxic ions.136,151 The pH-dependent dissolution of ZnO is a classic example:ZnO(s) + 2H+(aq) Zn2+(aq) + H2O(l)While this mechanism is compelling and supported by significant evidence,152 a critical perspective acknowledges the immense difficulty in experimentally deconvoluting these two toxicity vectors

The distribution of patients across different age groups screened into the studies is illustrated in the figure

Bronchoalveolar lavage (BAL)