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Targeted genetic diagnostic tests in blood may be considered depending on disease presentation and family history (particularly including whole mtDNA genome analysis or POLG1 sequencing)

Limitations and bottlenecks Several bottlenecks continue to constrain clinical adoption of integrated reproductive multi-omics

It is a crucial regulator of energy homeostasis and acts as a sensor detecting the ratio of AMP/ATP monitoring the cellular energy (widerska et al., 2021)