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This provides direct cellular and molecular evidence for understanding the mechanisms of ferroptosis imbalance in AKD and CKD pathogenesis while offering crucial theoretical and data support for subsequent intervention strategies targeting ferroptosis-promoting pathways in kidney diseases (e.g., cell type-specific iron metabolism modulation and lipid peroxidation inhibition)

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While there is a theoretical risk that CP antibodies could enhance disease via ADE, case reports in SARS-CoV and MERS-CoV outbreaks showed that CP therapy was safe and was associated with improved clinical outcomes 89,90

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Mus81-mms4 functions as a single heterodimer to cleave nicked intermediates in recombinational DNA repair

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