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Indeed, immunoblot analysis revealed significantly decreased protein levels of FASN in livers from GSH-depleted mice (Figure 5, I and J), without decreased levels of Fasn mRNA (Figure 5K)

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doi:10.1126/scitranslmed.3003504

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Although this finding is promising, many glycocalyx enzyme-targeting therapies require the oral administration of dietary supplements for a few weeks, which is virtually impossible for patients with sepsis

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