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In contrast, this treatment significantly downregulates the expression of cholesteryl esters (CEs) and TAGs by inhibiting the de novo synthesis of cholesterol and fatty acids, as demonstrated by isotope-tracing experiments and the downregulating effects of SREBF2 and ACLY expression 106

[DOI] [PMC free article] [PubMed] [Google Scholar] 6.Liyanage T., Toyama T., Hockham C., Ninomiya T., Perkovic V., Woodward M., Fukagawa M., Matsushita K., Praditpornsilpa K., Hooi L.S., et al