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In extreme instances, orthopedic diseases can even result in life-threatening complications

For BDNF transcriptomic endpoints, endotoxin testing below 0.25 EU per mg is additionally relevant, since lipopolysaccharide contamination will independently drive neurotrophin and cytokine expression

Thioredoxin in the cardiovascular system

These pathways are activated by various extracellular stimuli, such as cytokines, chemokines, and oxidative stress, which are prevalent in asthmatic conditions [119, 121]