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One of the major contributors to PDAC progression and metastasis are cancer-associated fibroblasts (CAFs), which block drug delivery and create a hypoxic microenvironment

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These findings agree with those of our previous studies showing increased IgA/IgM response to LPS of 6 different Gram-negative bacteria in CFAS-D, indicating an increased bacterial translocation ( Our enrichment analysis also showed an association between the IO&NS subnetwork and the lactoferrin (LTF) danger signal response pathway