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10.1038/s41586-019-1103-9 22 BermanH

- Antioxidant Defense: It reduces oxidative damage caused by mycotoxins, protecting cellular structures

ACSL4 catalyzes the attachment of free PUFAs to coenzyme A to generate PUFA-CoAs, which are re-esterified and incorporated into phospholipids (PLs) by LPCAT3 to form PUFA-containing phospholipids (PUFA-PLs) ( The downregulation of PUFAs in tumour cells is associated with ferroptosis evasion and the promotion of tumour growth (Figure 1