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From pretreatment to presurgery, the mean increase in hemoglobin in the 600 Units/kg weekly group (1.44 g/dL) was greater than that observed in the 300 Units/kg daily group

10.1038/nature19339 64 KulshresthaA.SharmaV.SinghR.SalotraP

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These genetic disorders demonstrate that intact ubiquitin-dependent protein degradation is not merely supportive but fundamentally required for neuronal integrity

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